The third most prevalent illness in India is a UTI, which may afflict patients both inside and outside of hospitals and affects individuals of all ages. The prevalence of UTI is steadily rising, which is bad Antibacterial medicine use increases as a result of Introduction 2 and has an impact on people's socioeconomic lives. Penicillins, oxyminocephalosporins, monobactams, and cephalosporins up to generation 3 and 4” are only a few examples of the practically all -lactam antibiotics that can be hydrolyzed by extended-spectrum -lactamases (ESΒLs). ESΒLs are found in a variety of bacteria from the “Enterobacteriaceae family, including Klebsiella pneumoniae, E. coli, Proteus mirabilis, and Salmonella species”. The aim of the investigation is to screen the extended spectrum beta-lactamases (ESΒLs) production from the Klebsiella isolates obtained from the hospital. Method is to in case of admitted (IPD) patients from various departments urine was collected as freshly voided mid-stream specimen or by catheterization or suprapubic aspiration and sent to the laboratory. Inclusive criteria is 300 non-duplicate pure cultures of K. pneumoniae isolated from urine samples of patients > 10yrs of age whereas, exclusive criteria is to Urine samples of patients < 10 years of age were excluded from the study. In the screening test, detection of resistance to one or more of the four of these drugs (ceftazidime, cefotaxime, ceftriaxone and aztreonam) employed were considered to be an ESΒL producer 226 (75.3 %) isolates were found to be resistant. A very high resistance of ESβL producers were seen towards ceftazidime, cefotaxime and ceftriaxone.