Introduction: A malignancy with a particularly high fatality rate is gallbladder cancer. Unfortunately, it is standard practice to throw away gallbladder samples after cholecystectomy if cancer is not detected. In order to determine the prevalence of gallbladder cancer in patients who had undergone cholecystectomy, routine histopathology specimens were examined, along with their clinico-pathological characteristics. Methods: This was a two-year cross-sectional study that included 442 individuals who had cholecystitis that was either acute or chronic and was brought on by cholelithiasis and treated with cholecystectomy. During surgery, gallbladders that displayed glaring anomalies suggestive of localized or infiltrative cancer were also disregarded. Each and every gallbladder specimen was sent for histopathological analysis. Results: During a two-year period, 442 individuals with symptomatic gallstones underwent cholecystectomy surgery. 1:4 was the male to female ratio. 29.4 percent of the patients were discovered in their fourth decade of life. The majority of patients (95.2%) complained of upper abdominal pain that had varied in intensity. For histopathology, all the samples were sent. In 380 instances (85.9%), chronic cholecystitis was present (including intestinal metaplasia and dysplasia). In 50 of the patients (11.3%), acute cholecystitis was present (including empyema and mucocele). Twelve gallbladders (2.7%) had cholelithiasis and signs of adenocarcinoma with varied degrees of differentiation. Conclusion: Gallbladder carcinoma is frequently discovered by accident. As the only method for early detection of subclinical cancers, we strongly advise routinely sending all cholecystectomy tissues to the histopathology lab.