Mast cells are granular cells and native of connective-tissue. They mostly associates with type-1 allergic reactions. Despite their link with multiple kind of allergic reactions, these mast-cells are also related with numerous pathognomic conditions of oral- cavity. Mast cells are usually acts after stimulated by allergic or any pathologic condition, by secreting cytokines or other mediators. Number of mast-cells in normal physiological condition and other pathologic condition is quite important, due to their significance in severity of disease-process. Hence, this review summarizes the relationship of mast-cells among normal physiological condition and different pathologic conditions of oral-cavity.