Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, represents a global health challenge with increasing prevalence. While the classic understanding of diabetes primarily revolves around insulin resistance and impaired beta-cell function, emerging evidence highlights the pivotal role of inflammation in its pathogenesis. This abstract provides an overview of the intricate interplay between inflammatory processes and the development and progression of diabetes.The role of inflammatory pathways extends beyond insulin resistance, influencing the onset of type 1 diabetes as well. Autoimmune destruction of pancreatic beta-cells involves the activation of inflammatory responses orchestrated by T cells and other immune effectors. Understanding these molecular and cellular processes opens avenues for novel therapeutic interventions targeting inflammation to modify the course of diabetes. In conclusion, this abstract highlights the multifaceted role of inflammation in the pathogenesis of diabetes, encompassing both type 1 and type 2 diabetes. Targeting inflammatory pathways presents a promising approach for the development of novel therapeutic strategies, emphasizing the need for a comprehensive understanding of the immune-metabolic interplay in diabetesmellitus.