Parkinson's disease is a neurological condition characterized by symptoms including rigidity, tremors, postural instability, and bradykinesia. It affects approximately 6.3 million individuals worldwide, spanning various racial and cultural backgrounds. The impairment of motor skills and cognition impacts patients' diets, nutrition, and overall health, leading to compromised oral hygiene and an increased risk of dental issues such as caries, periodontitis, and eventually, edentulism. Compassionate care marked by attentiveness and empathy is essential in treating these patients, alongside educating their families about the disease. This article provides an overview of the causes, clinical manifestations, orofacial observations, and prosthodontic strategies for managing Parkinson's disease patients.