Operative dentistry has utilised regenerative methods to treat dental disease for many years. Clearly, the use of calcium hydroxide to encourage reparative or reactive dentin is one such treatment technique. The emergence of tissue engineering enables dentistry to advance its use of regeneration as a guiding principle for treating oral disease. Tissue engineering is a multidisciplinary field of study that combines biology, engineering, and clinical sciences to create new tissues and organs. It is founded on fundamental principles involving the identification of relevant cells, the building of conducive scaffolds, and an understanding of the morphogenic signals necessary to stimulate cells to rebuild missing tissues. This study focuses on the presentation and discussion of existing material on the engineering of enamel, dentin, and pulp, as well as complete teeth. Clearly, significant obstacles must be addressed before such tactics may be routinely employed in the clinic to treat patients. Existing research, however, indicates that the engineering of new dental structures to replace tissues lost as a result of caries or trauma will have a position in the future of operative dentistry.