Human beings are longing for a healthy long life in terms of physical, spiritual and psychological parameters from time immemorial. However aging is a natural inevitable phenomenon associated with adverse progressive changes leading to decline in vigor etc, as a result human body is vulnerable to many diseases. Many factors accelerate this universal phenomenon like malnutrition, emotional conflicts, mental imbalances due to current hectic life schedule, chemical and radiological hazards followed by trauma and various diseases. Moreover, towards middle age, the rate of catabolic events happening in the body increases considerably to a higher extent. These in turn cause digestive and metabolic disturbances somehow linked with stress and anxiety. These interfere with the production of proper quantity and quality of Agni (bio-digestive fire) resulting quantitative and qualitative depletion in Ojas (essence of all tissue elements) along with its distribution to various Dhatus (tissues) and Avayavas (organs). Rasayana chikitsa (Rejuvenation therapy) is one of the most indispensable branches of Ayurveda which enhances rasa (digestive end products) and thereby helps to attain longevity, immunity etc. The Rasayana therapy maintains the balance between anabolism and catabolism in the body in the form of anti-oxidants, immune-modulators and as anti-aging agents. It is a blessing for the management of multidrug drug resistant cases as well as immune-compromised patients in addition to routine disease management. In this article author tried to elaborate various ancient Rasayana methods mentioned in the Indian traditional system of medicine for the preserve the healthiness specifically substantiated basis of current clinical research outcome in respect to organ wise, age wise & disease wise.