The antibiogram is useful for tracking trends in antimicrobial resistance over time, including information specific to an ICU or ward or comparing inpatients and outpatients. A cumulative antibiogram will be compiled for our institution as part of our antibiotic stewardship programme.This prospective study was conducted by the Department of Microbiology, Santosh Medical College & Hospital, Ghaziabad, Uttar Pradesh from January to December 2021. The organisms and their susceptibility patterns were collected and cumulative antibiograms were prepared. A total of 1395 specimens were received in the Microbiology laboratory from various departments of Santosh Hospital, Ghaziabad, for culture and sensitivity; 450(32.2%) samples yielded a positive culture, whereas 945(67.7%) samples yielded no growth. It is crucial to try everything possible to choose wisely. Antibiotics balance the need for a broad spectrum of empiric coverage of potential microorganisms with the need to preserve effective available antibiotics when they are absolutely necessary.