The present study work undertaken with the intend to develop a topical hydrogel formulation of dapsone 7.5% which would attenuate the first pass metabolism associated with an oral administration. Dapsone has low solubility and low permeability and classified as BCS class II drug as per biopharmaceutics classification system. The dapsone is formulated as hydrogel which premeditated to application by topical route for the treatment of skin disease acne vulgaris. The QTPP was define considering the product quality and efficacy. CQAs are drug product quality metrics and identified for process validation. The hydrogel formulation containing dapsone was optimized by using central composed design (CCD). Concentration of polymer’s and concentration of pH modifier were identified as independent variables and drug release, pH measurement, viscosity and extrudability were dependent variables. Hydroxypropyl methyl cellulose (HPMC) with concentration of 5 – 10 %, Sodium Carboxymethyl Cellulose (Sod. CMC) with 5 – 10 % as pH modifier Triethanolamine (TEA) with 2.5 – 7.5 %. The optimization study confirms with 20 runs which designate a high level of prognostic skill of response surface methodology. The formulations characterized by drug content, pH, extrudability, residence time, drug release and viscosity. From the obtained results of drug release it was concluded that an optimized formulation shows a complete drug release. An accelerated stability study analysis showed acceptable results for an optimized trial formulation.