The obsession for drugs and alcohol is a global predicament, which affects almost every country in the world, both developed and developing. Current evidence from around the world divulges an ongoing upward trending the misuse of psycho-active drugs. However, the data available, because of the nature of the problem and current data gathering process are often of poor quality so that the true dimensions of the problem are underestimated. Epidemiological data point to an augment of drug abuse in India, particularly among young adolescent. This is a matter of deep concern and requires strategic intervention, especially for the school and out of school population of the country.