Patients in critical condition are more likely to get infections caused by different antibiotic-resistant microorganisms. This goal of the study was to identify the common isolates and the patterns of antibiotic resistance in these patients. 794 samples throughout were examined and 18% of the samples had growth, producing 143 organisms. Pseudomonas sp, Acinetobactersp, Escherichia coli, and Klebsiellasp, Staphylococcus sp, Enterobactersp, Enterococcus sp, Proteussp, and Serratia sp. were the main organisms isolated. There were more than 50% of third generation cephalosporin-resistant E. coli, Pseudomonas, Proteus and Acinetobacter strains. Colistin, tigecycline, carbapenems, and quinolones were evidently sensitive to the majority of the identified pathogens. All significant isolated organisms were resistant to cephalosporins, penicillins, and aminoglycosides