IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

Optimization of a Robust HPLC Method for Abemaciclib and Its ProcessRelated Impurities; Characterization of Degradation Products Using LCMS/MS

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Srinivasa Rao Katta1*, Gajanand Thakre2

Abstract

The current study was undertaken to explore an innovative approach that employs liquid chromatography (LC) and liquid chromatography-mass spectrometry (LCMS/MS) for the resolution, identification, and characterization of minute quantities of degradation products (DPs) of abemaciclib, without the need for their isolation from reaction mixtures.

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