IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

DOSE DEPENDENT HAEMATOLOGICAL EFFECTS OF MONOCROTOPHOS AND AMELIORATIVE ROLE OF EMBLICA OFFICINALIS ON WISTAR RAT

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M. Chidambara priya,Dr. P. Vanitha Pappa

Abstract

For many years, agriculture has utilised the organophosphate pesticide monocrotophos (MCP). Since it is exposed to the agricultural community on the job, determining its safe and harmful levels has become a critical problem. The goal of this study was to determine if Emblica officinalis might protect albino rats from the harmful effects of monocrotophos. For 30 days, monocrotophos was given at sub-lethal dosages of 0.5 mg/kg and 1 mg/kg body weight. Wistar rats that were mature and in good health were divided into five groups: GI, GII, GIII, GIV, and GV. In comparison to the control, the findings obtained showed substantial changes in the values of Hb, RBC, WBC, PCV, MCV, MCH, and MCHC. The drop in RBC indicated that the rats' circumstances were anaemic. In the current study, there was also a notable increase in WBC. But following Emblica officinalis (20 mg/kg/bw) therapy, those parameters significantly changed in the monocrotophos-treated group. Therefore, it can be inferred from the aforementioned study that although the entry of these dangerous pesticides (monocrotophos) into our bodies cannot be stopped, the problem can be resolved to a large extent by using these medicinal plant extracts as potent antidotes, normalising the physiology of the body, and maintaining the cellular integrity and normal functioning of the system.

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