The term "cardiovascular disease" covers a wide range of illnesses, from peripheral vascular disease to coronary artery disease, that have an impact on the heart and blood arteries of the body. The growth factor-stimulated serine/threonine kinase known as MSK1 is involved in the control of gene transcription and the activation of pro-inflammatory cytokines. One polypeptide, MSK1, has two distinct protein kinase domains, making it a dual kinase. at 2.0 A and 2.5 A resolutions, we report the active conformation of the crystal structures of its Cterminal kinase domain in apo form and in association with a nonhydrolyzable ATP analogue