The current study was designed to evaluate the productive benefits of Musa paradisiaca L. pseudostem exudate against struvite stones. Musa paradisiaca Linn. is widely distributed throughout various tropical regions. Exudate (stem juice) of the pseudostem part of M. paradisiaca Linn.is highly beneficial and imperative naturally available medicine for human kidney. The present study was carried out to investigate the diminished effect of exudate on struvite stone. The M. paradisiaca L. Pseudostem Exudate reduced the crystal size and inhibited crystal growth. Because the experimental exudate possessed the biologically efficient secondary metabolites. Mainly, three different bioactive compounds were identified by GCMS technique such as Tricyclo[8.4.1.1(3,8)hexadeca-3,5,7,10,12,14-hexaene-2,9-dione,anti-, Olean-12-ene-3beta,28-diol and 2H-Pyran, 2-(7-heptadecynyloxy) tetrahydro. Besides the findings clearly showed that Olean-12-ene-3beta,28-diol biocompound contains medicinal property especially anti-urolithiatic effect against the struvite stone. Hence, the present research could be opined that M. paradisiaca L. pseudostem exudate might be used as healing agent for the treatment of urinary kidney stone disease.