Antioxidant activities of Anaphyllum wightii Schott rhizome was estimated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and nitric oxide (NO) scavenging activity at different concentrations. The results are compared with the standard ascorbic acid. The scavenging effect increases with the concentration of standard and samples. Overall observation shows, among all the tested solvents ethyl acetate shows significant inhibition percentage followed by aqueous, methanol and ethanoic extracts. DPPH radical scavenging activity of ethyl acetate extract possess promising free radicle scavenging percentage 52.19 at lower concentration that is 10 µg/ml. The inhibition percentage of ethyl acetate and aqueous extract is 63.31%, 63.52% at 100 µg/ml concentration. For DPPH assay, Ascorbic acid at a concentration of 10 µg/mL exhibited 60.32% of inhibition and for 100 µg/mL 98.39%. NO scavenging activity shows significant free radicle inhibition percentage 48.04 at lower concentration that is 10 µg/ml. The inhibition percentage of ethyl acetate extract exhibit 71.50 % scavenging activity at 100 µg/ml concentration and the standard ascorbic acid shows 89.94% of inhibition in NO scavenging assay. The present study revealed that the Anaphyllum wightii rhizome has significant radical scavenging activity that may be useful for their medicinal functions.