The antitumor activity of the ethanolic extract of Dry fruit of ficus carica (EFC) has been evaluated against Dalton’s ascitic lymphoma (DAL) in swiss albino mice at the dose of 250 and 500 mg/Kg, body weight. The experimental parameter used were tumor volume, tumor cell count, viable tumor cell count, mean survival time and increase in the life span to assess antitumor activity. The extract administered orally for 14 consecutive days to tumor bearing group of animals. The extract increases the life span of DAL treated mice and restore the hematological parameter life span of DAL treated mice and restore the hematological parameters as compared with the DAL bearing mice in dose dependent manner. The Study revealed that the EFC showed significant antitumor activity in tested animal models.