Diet and Gut microbiota each have a direct impact on many chronic, inflammatory disease and metabolic disease.The role of the Pathya aahar (Healthy diet) and gut microbiome in health and Aamvata (Rheumatoid Arthritis) helps to provide a scientific knowledge of key concept in Ayurveda. In this review we’ll look at how diet changes the Gut microbiome and how it triggers Aamvat ( Rheumatoid Arthritis).There is evidence that some foods have pro and anti inflammatory effects mediated by diet related metabolites. Pathya ahar (Healthy diet) in Rheumatoid Arthritis are metabolized into SCFA by gut microbiome. Apathya aahar(Unhealthy diet) in Rheumatoid arthritis are metabolized in LCFA and VLCFA.