Analysis of heavy metals like Cadmium(Cd), Chromium(Cr), Nickel(Ni), Zinc(Zn), Lead(Pb) and Arsenic(As) in commercially important edible bivalve Meretrix meretrix was carried out from September 2021 to October 2022 in two estuaries of Karnataka. The samples were collected from Kali (14080’58”N & 74014’26.2”E) and Aghanashini Estuary (14052’25.6”N& 74036’67.5”E) during low tide. Heavy metals were analysed by using ICP-OES OPTIMA 8000(Perkin Elmer). During the present investigation on Meretrix meretrix, highest concentration of Chromium 103.10 ppm at Aghanashini was observed, which are much higher than permissible limits (12 ppm) as per Indian standards. Permissible limit of Zinc is 40 ppm, whereas higher concentration of 110.90 ppm at Kali was observed, which was much higher than the permissible limit. Nickel 20.84 ppm at Kali was observed which is higher than permissible limit (0.5 to 0.6 ppm). Whereas, 2.53 ppm of Cadmium was observed in Kali estuary which was a slightly higher than permissible limit (2.0 ppm). 7.61 ppm of Arsenic was observed at Aghanashini which was in low concentration than permissible limit (86.0 ppm).From above findings it is concluded that bivalves (Meretrix meretrix) from these two estuaries are not safe for consumption.