Health diseases are increasing day by day due to life style and hereditary. In this aspect, heart disease is the most important cause of demise in the human kind over past few years. The objective of this paper is to predict the Heart Disease by applying Artificial Neural Network using swarm Intelligence algorithm. Swarm intelligence (SI) is relatively new interdisciplinary field of research. The Swarm-based algorithms have recently emerged as a family of nature-inspired, population-based algorithms that are capable of producing low cost, fast, and robust solutions to several complex problems.