The utilization of medicinal plants for therapeutic purposes has been an integral part of traditional medicine for centuries. Modern pharmacology acknowledges the profound potential of medicinal plant compounds in drug discovery and development. However, the conventional methods employed for extracting, isolating, and analyzing these bioactive compounds often involve hazardous chemicals, high energy consumption, and generate copious amounts of waste, posing environmental and health risks. The integration of green chemistry principles into the analysis of medicinal plant compounds offers a sustainable approach towards drug discovery. Green chemistry emphasizes the design of chemical processes that minimize the use of hazardous substances, reduce energy consumption, and generate minimal waste. This abstract explores various green chemistry methodologies such as microwave-assisted extraction, supercritical fluid extraction, and ultrasound-assisted extraction, which have gained prominence in the extraction of bioactive compounds from medicinal plants. Additionally, green analytical techniques including high-performance liquid chromatography (HPLC) coupled with green solvents and eco-friendly detection methods contribute to reducing the environmental footprint of medicinal plant compound analysis. By adopting green chemistry principles, researchers can enhance the sustainability of medicinal plant compound analysis while maintaining the efficacy and safety of therapeutic agents. This abstract underscores the importance of integrating green chemistry practices in the pharmaceutical industry to promote environmentally benign approaches to drug discovery and development.