Background: Primary care physicians and gastroenterologists both can find chronic abdominal pain difficult to diagnose and treat because of the breadth of the possible causes and the extent to which the workup is frequently fruitless. The vast majority of individuals with persistent abdominal pain have a benign cause or a functional problem (such as irritable bowel syndrome) because of the absence of red flag characteristics that precede more acute conditions. Healthcare systems are strained by the high price tag of diagnostic testing. When patients are seen in the primary care setting, it is best to take a methodical approach to both the evaluation and implementation of their care. Investigating unexplained stomach discomfort requires first performing a thorough history and physical examination. Clinical characteristics, warning symptoms, and symptom severity should guide the scope and timing of diagnostic investigations. In this article, we'll look at the diagnostic methods used by primary care physicians for assessing persistent abdominal discomfort. Focused Messages: Primary care physicians are responsible for diagnosing and treating patients with both organic and functional diseases, referring patients to specialists when necessary, and treating the source of pain. After all possible organic pathology has been ruled out, only then should the functional abnormalities be evaluated. The patient should be referred for psychological support (e.g., cognitive therapy) in addition to the existing pharmaceutical therapeutic alternatives after a diagnosis of functional pain has been established, and further testing should be avoided.