The antibiotic used to treat acne may produce unwanted side effects and antibiotic resistance. Polyherbal formulations are herbal preparations that incorporate a variety of therapeutically effective plant extracts. Thus this study aims at utilizing the synergistic medicinal effect of Basella alba, Boerhavia diffusa, and Kaempferia galanga in form of gel. The colour of all formulations was observed to be brown.For the formulations F1 to F5 the transparency& consistency was appreciable with zero sediments. But F6 reported to have sediments with thin and runny consistency. The washability of formulation fromF1 to F5 was better but for F6 it retained minimal residue after rinsing.Extrudability ranged from158±4 to 196±3 g.The pH range observed in this case varied from 6.5±0.1 to 6.9±0.3. Further maximum drug content of 0.785 was observed in F4 formulation. The anti -acne activity of F4 formulation was checked by well diffusion method using marketed formulation named Clintop gel as standard. In case of Clintop gel at 100µg/ml the zone of inhibition was recorded as16±0.57 mm while in case of polyherbal gel at 100mg/ml concentration the zone of inhibition for F4 was noted as 17±0.5mm. Thus, the formulation of gel F4 had a synergistic effect of all plant extracts were used to treat mild acne vulgaris.