The aim of this study was to develop Oral soluble film of Dapagliflozin using permeation enhancer. The oral soluble films are more beneficial in comparison to the tablets and capsules because oral films tend to dissolve within a minutes after placing on tongue. Dapagliflozin is a drug of choice used in the treatment of diabeties. Administering the drug by oral soluble route enhances the bioavailability and oral films bypasses the first pass metabolism of the drug. Oral soluble films are the advancement in the solid dosage forms and having more patient compliance. Films were prepared by using solvent casting method. As Dapagliflozin is BCS class III drug , Dimethyl sulphoxide plays important role in formulation as it used as permeation enhancer. Poly ethylene glycol 400 was used as plasticizer and HPMC used as Polymer. Sodium saccharine was used to mask the bitter taste of the drug. Film was evaluated for drug content, disintegration time, dissolution, thickness, tensile strength, folding endurance and surface pH. The optimized formulation F4 exhibited acceptable folding endurance (120), disintegration time (67 sec) and drug release of 99.92% in 300 sec. It can be concluded from the study that the oral soluble films of Dapagliflozin can be a potential novel drug dosage form.