Chemical entities known as drugs should pass the physicochemical properties to satisfy the category of drug. It should be stable and should exhibit its activities devoid of undue adverse effects. It was observed that very common drug diclofenac sodium degrades in aqueous media at a drastic rate. In the present study, we evaluated the ways to shield the diclofenac sodium which can delay the degradation or release and thereby increasing its efficacy.In the present work diclofenac sodium microspheres were prepared using various polymers like gelatin, ethyl cellulose by using solvent evaporation and ionic gelation methods.