The objective of the work was to utilize the colon-specific drug delivery for the treatment of cancer disease to achieve better therapeutic effects and lesser side effects. Colon-targeted drug delivery systems for curcumin were developed. Curcumin (CUR) microspheres were designed to control and target drug release to the colon. Drug delivery to colon encounters obstacle such as absorption and degradation in the upper GIT. The optimum drug delivery to colon requires avoidance of the absorption and metabolic breakdown of these drugs from the stomach and small intestine. Therefore, pH sensitive polymer Eudragit S 100 was chosen, which can bypass the upper GIT and can retain on the surface of colon ensures local and targeted effect.Curcumin can chelate various metal ions to form metal complexes of curcumin, which can show greater effects than curcumin alone. In this work the curcumin complex with zinc metal for its synergistic effect in cancer treatment.