IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

EVALUATION OF CRUDE BANANA POWDER AS FORMULATION ADDITIVES AND COMPARISON OF ITS MUCOADHESIVE PROPERTY WITH CARBOPOL 934P

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Mr. M. Ranadheer Kumar, Dr. Ch. Kishore, Mrs. S. Sabitha

Abstract

The current study compares the mucoadhesive characteristics of crude banana powder with carbapol 934P polymer and evaluates it as a formulation aid. Diclofenac Potassium is a model medication used in tablet formulation and assessment. To extend the medicine's contact duration with the absorbing membrane, tablet formulations that adhere to the gastric mucus or the surface of epithelial cells are helpful in drug administration. Isopropyl alcohol was used in the direct compression, aqueous wet granulation, and non-aqueous wet granulation methods used to make the tablets. A total of fifteen formulations were made with different amounts of polyvinyl pyrrolidine, crude banana powder, and carbapol 934P. Weigh variation, hardness, friability, assay, disintegration, mucoadhesive strength, and an in vitro drug dissolution research were all assessed for the tablets. Using a USP dissolving apparatus type I, the in vitro release of diclofenac potassium was carried out under sink conditions (phosphate buffer PH6.8, 37±0.5ºC, rpm 50). The mucoadhesive properties of carbapol 934P were superior to those of banana flour when the polymer concentration was raised. Force of adhesion rose from 1.716 N to 4.684 N in the case of Carbapol 934P with an increase in polymer concentration from 10% to 60%, while force of adhesion increased from 0.662 N to 1.716 N upon an increase in banana flour concentration from 10% to 60%, respectively. This indicates that Carbapol 934P and crude banana flour both have mucoadhesive properties, but that Carbapol 934P has superior mucoadhesive properties. The aqueous wet granulation technique formulations of Carbapol 934P and banana flour had a prolonged effect; the F2 formulation for Carbapol 934P and the F6 formulation for crude banana exhibited the best sustained impact. When Carbapol 934P was included in the formulation, a more sustained effect was seen.

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