Mirabilis jalapa L. recurrently known as the Four O’clock plant is a perennial herbaceous medicinal plant adroitly known for its traditional uses. Traditionally, the plant is worn in the treatment of a diversity of human ailments like skin diseases, cathartic, purgative, stomachic, tonic, anti-dysenteric, anti-parasitic, wound healing properties, digestive, stimulant etc. The dynamic constituents delineated in this plant encompass alkaloids, flavonoids, phenols, glycosides, tannins, saponins, lignin and carbohydrates. A quota of pharmacological pursuits is outlined in this plant like anti-diabetic, anti-inflammatory, anti-oxidative, anti-bacterial, anti-microbial, anti-fungal, anti-spasmodic, antinociceptive, anti-viral, diuretic, anthelmintic and urinary tract disorder. The contemporaneous appraisal is, therefore, sight on condition that a review of the literature on its ethnomedicinal, phytochemical and pharmacological possessions.