Seismic events persistently provide substantial dangers to populations throughout the globe, underscoring the pressing requirement for inventive strategies to bolster the ability of buildings to withstand earthquakes. This research article explores the crucial function of sophisticated structural design methodologies in strengthening buildings and infrastructure to withstand seismic stresses. This article offers a comprehensive review of the latest tactics and technologies used to reduce structural vulnerabilities and minimise the effect of earthquakes. It draws on a detailed analysis of scholarly literature, empirical investigations, and real-world experiences. The study begins by explaining the fundamental principles of seismic resilience and outlining the inherent difficulties encountered by conventional building designs in areas prone to earthquakes. Subsequently, it delves into a thorough examination of the conceptual underpinnings and real-world applications of sophisticated structural design approaches. These approaches include a range of creative solutions, such as base isolation systems, energy dissipation devices, hybrid structural systems, and the use of modern materials with excellent seismic performance properties.