Milk of a mammalian was specially designed for the slight immunization with the help of the colostrum and the transition milk, which fulfills the nutritional requirements of the new born infants. Donkey milk has been well known for its therapeutic, cosmetic and nutritional aspects from the ancient times. The donkey milk was suggested for the orphan babies and infants who are sick with different infectious diseases. Recently due to nutritional composition which is equal to the human milk and having very good probiotic properties and disease prevention characteristics is giving a new insight to the human life. Furthermore, the important characteristics like anti-microbial, anti-inflammatory, anti-diabetic, anti-allergy with good nutritional profile with essential proteins, essential fatty acids help in the healthy life. This study gives the healthy prospects of benefits of non-ruminant milk and the future prospects of the donkey milk