Antimicrobial drug resistance has emerged as a significant global health threat, jeopardizing our ability to effectively treat infectious diseases. Overuse and misuse of antibiotics, coupled with the lack of development of new antimicrobial agents, have contributed to the rapid spread of resistance among bacterial, viral, fungal, and parasitic pathogens. This review provides an overview of the current status of antimicrobial drug resistance, highlighting key mechanisms of resistance, the impact on patient outcomes and healthcare systems, and the urgent need for concerted efforts to address this critical issue. Strategies to combat antimicrobial resistance include antimicrobial stewardship programs, development of novel antimicrobial agents, promotion of infection prevention and control measures, and public education campaigns to raise awareness about appropriate antibiotic use. Antimicrobial drug resistance poses a significant threat to public health globally. This review examines the current landscape of antimicrobial resistance, including its mechanisms, epidemiology, and impact on healthcare. Strategies to combat resistance, such as stewardship programs, development of new drugs, and alternative therapies, are also discussed.