Supplementary local anesthetic techniques (Buccal Infiltration and Intraligamentary Injections) are used to achieve adequate pulpal anesthesia by supplementing the initial Inferior Alveolar Nerve Block (IANB). There was no study found in Pakistani literature which compared these two supplemental techniques with 2% Lidocaine. This study was conducted to compare the frequency of success of buccal infiltration verses intraligamentary local anesthetic techniques with 2% Lidocaine in patients with irreversible pulpitis. METHODOLOGY: This randomized control trial was conducted in the Department of Conservative Dentistry and Endodontics, at Rama Dental College, Kanpur from Jan 2022 to June 2022. A total of 82 patients presented with irreversible pulpitis in the mandibular first molar were included in this study and divided in two groups of 41. Group A were administered Buccal Infiltration local anesthesia while Group B was administered Intraligamentary local anesthesia. RESULTS: The results of the present study showed significant difference between success rate of Buccal Infiltration (34.1%) and intraligamentary anesthetic technique (65.9%) with 2% Lidocaine.(p-value = 0.039). CONCLUSION: This study concluded that Intraligamentary is a better supplementary technique to achieve adequate pulpal anesthesia as compared to buccal infiltration with 2% lidocaine in mandibular molar teeth with irreversible pulpitis.