Weeds are plants that harm socio-economic, environmental, food security, biodiversity, ecosystem and human health. The present study aimed to assess the control and management efficiency of the most useful perennial weed species Subabul. Randomized Block Design was employed to control the Subabul in the R& D estates, KanchanBagh, Hyderabad. The chemicals of Glyphosate 41% (T1), Paraquat Dichloride 24% (T2), 2, 4-D sodium salt 80% (T3), Atrazine 50% (T4) and Vinegar 5% (T5) were applied in the field and studied with a Control (T6) in One acre on major weed of Subabul and observed the effects up to 75 days duration. Glyphosate 41% systemic herbicide application showed very effective performance by killing above-ground growth and deteriorating underground plant parts at 1.5%, followed by Paraquate Chloride at 24%. Vinegar showed eco-friendly, broad-spectrum, biopesticide activity and is suitable to control Subabul, especially on buildings/ structures. The study not found herbicide residues in the experimental area after 75 days.