This research study aimed to investigate the awareness, anxiety, and mental health of COVID-19 patients of northeast India. The second wave of novel coronavirus disease (COVID-19) has rapidly crossed borders and infecting people throughout India in general and northeast in particular. This pandemic leads to heightened levels of stress and anxiety in COVID-19 patients. An online survey was conducted using a structured questionnaire using a non-probability snowball sampling technique. A total of 342 responses were received online. The results of the study revealed that respondents had a moderate level of knowledge about the COVID-19 infection and adequate knowledge about its preventive aspects. The mental health of the COVID-19 patients was not found satisfactory. There is a need to intensify the awareness and address patients’ mental health issues during the COVID-19 pandemic.