The goal of this study is to assess the cost utility, cost effective and cost minimization analysis of chronic obstructive pulmonary disease patients in rural areas of Salem district, Tamil Nadu. A cross-sectional study was conducted among 100 patients in rural areas of Kondapanaickanpatty, Attayampatty over a period of six months (November 2020- April 2021). Among 100 COPD patients, 66 were male and 34 were female. Cost Utility Analysis shows that 52 patients had a total cost between 10001-20000 INR. Cost Effective Analysis shows that patients who were consulting in government hospital spent only indirect cost (AVE 7,706.84 INR). But patients who were consulting in private hospital spent both direct and indirect cost (AVE 20,176.73 INR). Cost Minimization analysis shows that the brand drugs which were prescribed to the study population such as Proventil (Inhaler), Budecort (Inhaler) and Efcorlin (Injection) are found to be very expensive but generic drugs by Jan Aushadhi is very less in cost when compare to alternate brands. Hence, we conclude that the treatment strategies practiced in both private and government hospital is similar, but the cost utilized is higher for patients who were consulting in private hospital than government hospitals. Patients in rural areas are better advised to take treatment in government hospitals thereby we can reduce the economic burden of patients and prefer generic drugs which are available at Jan Aushadhi store will reduce the cost of illness in the management of COPD.