Platelet-rich fibrin (PRF) has emerged as a promising adjunctive therapy in periodontology due to its unique biological properties and ease of preparation. This comprehensive review aims to explore the various applications of PRF in periodontal regenerative procedures and its potential benefits in enhancing wound healing, reducing inflammation, and promoting tissue regeneration. Key topics covered include the biological rationale behind PRF therapy, techniques for PRF preparation, clinical indications for its use in periodontal surgery, and evidence from clinical studies evaluating its efficacy. Additionally, this review discusses the limitations, future directions, and considerations for integrating PRF into routine periodontal practice.