There is an increase in activity in the synthesis of the Schiff base compounds as a reef of the future and biological activity is carried out with perfection. It is not only a biologic subject, but also a true multidisciplinary field in the many fields of chemistry and technology. The resultant compounds containing the azomethane groups (imine) have chemical and biological effects and are regarded to be 'privileged ligands' produced by condensing carbonyl molecules (aldehyde/ketones) with primary amino derivatives (Hine & Yeh 1967). These nitrogen-containing ligands and their structures played an essential part in the development of coordination chemistry owing to their synthesization, selectiveness, sensitivity, stability and unique magnetic characteristics towards the central metals atom (Garnovskii et al. 1993). Furthermore, Maillard reaction of different amino acids and reducing sugars such as glucose and ribose may be used to create Schiff base. The development of advanced glycemic end products (AGEs) is stabilised by the rearrangement of Amadori. Maillard reaction products may function as antioxidants, bactericidal compounds, anti-allergic and antimicrobial molecules, etc. and can be regulated via changes in dietary values and circumstances of processing and storage of various foods and drinks (Zhang et al. 2009). Moreover, the Schiff base and its metal complexes derive amino acids contain a broad spectrum of biological activities such as anti-inflammatory (Sondhi et al. 2006 and Chinnasamy et al. 2010, analgesic (Gyanakumari et al. 2010), anti-convulsant (Ali et al. 2012), anti-TB (Wei et al.) 2006, anti-oxidant (Avaji et al. 2009), antimicrobial and antitumor. The ship's base ligands are nevertheless not stable and susceptible to hydration and disintegrate when exposed to air (Sari et al. 2004). Schiffbases also have the capacity to kinetically stabilise because of their 'chelate effect,' and a wide range of effective catalytic reactions are used to controll various metals with varied oxidation states. In recent years, Schiff's transition metal complexes have been widely investigated in coordination chemistry primarily because of their excellent solubility in common solvents, extraordinary magnet and electronic characteristics, unique structural characteristics and significance to biological systems. The study of the vast number of ship bases and their metal complexes has garnered increasing attention owing to their enormous potential uses (Xie et al. 2010). The shipbases are usually categorised as bident, trident, tetradentate or polydentate, which with transition metal ions may form very stable complexes. Much more special attention has recently been paid to the multi-dented basemetal complexes in the area of optical materials, catalytic materials, the drug design, biological samples and chemical sensors etc. There has recently also been considerable interest in designing metal transition complexes as medicines and diagnostic agents in the area of medical chemistry.