In the realm of wireless communications, Multiple Input Multiple Output Orthogonal Frequency Division Multiplexing (MIMO-OFDM) has emerged as a pivotal technology for enhancing data rates and system reliability. However, the performance of MIMO-OFDM systems is significantly affected by channel variations, particularly in time-varying environments. In this paper, we delve into the analytical research of MIMO-OFDM in time-varying channels employing Digital Signal Processing (DSP) techniques. We investigate the challenges posed by channel dynamics and explore various strategies to mitigate their effects. Through analytical modeling and simulations, we assess the performance of MIMO-OFDM systems in dynamic channel conditions and propose novel DSP-based solutions to enhance system robustness and efficiency. Our findings provide valuable insights into the design and optimization of MIMO-OFDM systems for real-world deployment scenarios.