Different medications are used to treat cognitive deficiency in humans. It is also termed cognitive neuro enhancement. the most psychoactive substance in the world consumed by people is caffeine, others are L- Thiamine, creatine, nicotine, etc. its works by increasing blood flow in the brain due to which blood can use more oxygen. in this way, the individual can stay conscious for long hours. It acts as an energy booster and memory enhancer and also enhances the mood. Previous data about cognitive enhancers show that people who use drugs can work tirelessly for long hours rather than people who are not using them. However, it has several side effects which are described in this article. in this article, all the formations are summarized for a better understanding of this drug.