The analgesic and anti-inflammatory properties of methanolic extracts of Calotropis procera (Aiton) Dryand and Salix alba Linn were examined in white albino mice. Both plant extracts were evaluated for their analgesic and anti-inflammatory properties using plethysmometric assessment of formalin-induced paw edema in mice and the acetic acid writhing reaction. There was a dose-dependent analgesic effect shown by the extracts. In all tested dosages, S. alba extracts were more potent than aspirin, whereas C. procera extract demonstrated a notable reaction when compared to aspirin at doses as high as 62.5 mg/kg of plant extracts. The outcome also suggests that the extracts reduced the extent of the paw edema and shown inhibition of inflammation (*p<0.05), both of which were significantly greater than the aspirin's (100 mg/kg i.p.) inhibitory impact. Acute toxicity testing revealed that, at 125 mg/kg body weight, none of the plant extracts exhibited any appreciable toxicity. Alkaloids, tannins, and glycosides were detected by phytochemical screening in both plants. The results showed that there are significant analgesic and anti-inflammatory qualities in both extracts.