B.Sc Nursing students deal with the College setting as well as Hospital setting so, they come in contact with a large number of people, their level of knowledge can be increased with the implication of self instructional module on knowledge regarding the use of defibrillator among staff nurses. Pre-experimental design with pre-test and post-test with quantitative research approach used. Study was conducted in Rama Hospital and Research Centre, Mandhana Kanpur. 30 staff nurses were selected by using non-probability convenient sampling technique. Collected data was analyzed by using descriptive and inferential statistics, level of knowledge score reveals that in pre-test 2 is the minimum score and 14 is the maximum score mean score was 7.34 with SD 0.51. Post-test level of knowledge score reveals that in post-test minimum score is 7 and maximum score is 18 (mean score was 12.66 with SD of 0.46. Significant difference was found between pre-test and post-test knowledge score. In pre-test mean score was found to be 7.34 and SD 0.51 and post-test mean score was found to be 12.66 and SD 0.46. The comparison of mean pre-test and post-test knowledge score shows an extremely significant difference at p< 0.05 level (t value = 9.05) so hypothesis H1 is accepted which indicated that SIM on knowledge regarding the use of defibrillator is extremely effective. Key Words : SIM, Defibrillator.