INTRODUCTION Oral cancer will remain a major health problem and the incidence will increase by 2020 and 2030 in both sexes, however early detection and prevention will reduce this burden. The knowledge and awareness of oral cancer influences individuals in prevention and promotes health seeking behavior. A descriptive study was carried out to study to assess the effectiveness of health awareness teaching on knowledge regarding prevention of oral cancer among class-iv workers of selected hospital, Limda. AIMS The aim of the study to assess the effectiveness of health awareness teaching on knowledge regarding prevention of oral cancer among class-IV workers. METHOD An evaluative research approach was used with pre-experimental one group per-test, post -test design. the sample size of 120 Class-IV workers who met the sampling criteria. with convenient sampling technique. The data was collected using self-designed tool. The data was analyzed using Statistical Package for Social Services (SPSS 23) and STATA. RESULTS Results revealed that in pretest majority 66(55%) had average knowledge and 54(45%) had poor knowledge where as in post-test majority 73(60.8%) had good knowledge and 47(29.2%) had average knowledge regarding Prevention of Oral Cancer. Mean pretest knowledge score was 10.99±3.017 and in posttest was 19.89± 3.422 with mean difference of 8.90 and (t=value 20.65, df-119, p=0.001) was found statistically highly significant at p<0.05. Findings indicates that Health awareness teaching was effective in improving the knowledge regarding Prevention of Oral Cancer among class IV workers. Result revealed that age of class IV workers was found significant association with pre-test and post- test knowledge at p<0.05 level. Other demographic variables such as, religion, where are you living, marital status and educational status was not found any significant association with post-test knowledge score regarding Prevention of Oral Cancer among class IV workers. CONCLUSION The results of this study suggest that knowledge on oral cancer among study population are poor and need to be improved. Area of work found a significant association with the level of knowledge among study population. The study finding concluded that there is a clear need to inform and educate the class IV workers about the knowledge and prevention of oral cancer.