The Siddha system of medicine has Kuzhanthai maruthuvam as a branch of Pediatric medicine. This division has most of its formulation based on herbal origin. Even during this modern era, herbs have been used in traditional and folk lore practices based on experience based knowledge and they considered to be safe and time tested. Newborns and infants are susceptible to gastrointestinal and respiratory disorders. it has been found that nearly 70% of children between birth and 2 years of age, were prescribed at least 1 antibiotic. With most receiving multiple antibiotics exposure in the first 2 years of life is associated with the risk of immunological, metabolic, and neurobehavioral health conditions with childhood onset. Instead use of herbal medicines for minor pediatric issues that are commonly seen can be more beneficial as early exposure to antibiotics have been found to affect the infant microbiota and immunity. In this review some of the commonly used herbs such as Adhatoda vasika, Coleus aromaticus, Tachyspermum ammi, Azadirachta indica, Glycyrrhiza glabra and Piper betle have been selected and scientifically explored for their therapeutic action and safety.