The usage of fertilizers based on helpful microorganisms is becoming more popular as the need for ecologically acceptable farming methods grows. These organisms, which range from bacteria to yeasts and fungus, belong to a broad range of genera, classes, and phyla, and may promote plant nutrition via a variety of methods. Furthermore, research into the interactions between plants, soil, and other microbes is revealing insight on their interrelationships, potentially opening up new avenues for agricultural use. Despite the fact that inoculating plants with these microbes is a well-known technique, developing inocula that have a dependable and consistent impact in the field remains a barrier for their widespread usage. The technique used to make inoculas and the carrier used in the formulation are both critical to their success. This article focuses on how to address inoculation problems in order to enhance the effectiveness of beneficial microorganisms used to boost plant growth and production.