Skin cancers other than melanoma can be prevented and treated with photodynamic therapy (PDT). Clinically approved indications were previously limited to Bowen disease since 2006, nodular and superficial basal cell carcinoma, and actinic keratoses. The variety of signals has, nevertheless, been steadily growing.PDT is also used to treat leishmaniasis and other non-malignant disorders including acne vulgaris, as well as to delay the signs of premature ageing brought on by sun exposure. The concentration and localisation of the photosensitizer in the diseased tissue, as well as the light dose given, all affect the generation of reactive oxygen intermediates like singlet oxygen.[1-2] Either immunomodulatory effects that improve inflammatory skin conditions or cytotoxic actions that destroy tumours are induced. PDT has been demonstrated to be quite effective in treating superficial non-melanoma skin cancer despite its low degree of invasiveness.The outstanding cosmetic outcomes following treatment are also advantageous.