As a Rasayana, Withania somnifera (Ashawagandha) is a highly regarded plant in the Indian Ayurvedic medical system (tonic). It's used for a variety of ailments, but most notably as a nervine tonic. Many scientific researches were conducted in light of these facts, and its adaptogenic and anti-stress properties were thoroughly investigated. It increased the stamina of rats during a swimming endurance test and avoided changes in ascorbic acid and cortisol concentration in the adrenal glands caused by swimming stress in experimental animals. Stress-induced stomach ulcers were significantly reduced after pretreatment with Withania somnifera (WS). On Chinese Hamster Ovary (CHO) cell cancer, WS has an anti-tumor impact. It was also shown to be helpful in animals with urethane-induced lung adenoma. Long-term therapy with WS controlled the disease in certain instances of uterine fibroids and dermatosarcoma. It has a Cognition Promoting Effect and has been shown to be beneficial in youngsters with memory problems as well as elderly individuals with memory loss. It has also been shown to be beneficial in the treatment of neurological disorders such as Parkinson's, Huntington's, and Alzheimer's. It has a GABA-mimetic action and has been proven to stimulate dendritic development. It has an anti-anxiety impact and boosts energy and mitochondrial health. It's an anti-inflammatory and anti-arthritic drug that's been shown to be effective in Rheumatoid and Osteoarthritis patients. To establish its therapeutic effectiveness in stress-related illnesses, neurological disorders, and malignancies, large-scale investigations are required