EFFICACY OF BACOPA MONNIERI ON OXIDATIVE STRESS AND NA+/K+, CA2+ ATPASEACTIVITY AGAINST ALCOHOL INDUCED MYOCARDIAL DAMAGE

C. NarasimhaRao1; C. Nageswara Reddy 2; P. Sachidevi 3; G. Seethamma4; Corresponding authorD. VeeraNagendra Kumar

Authors

C. NarasimhaRao1 Author
C. Nageswara Reddy 2 Author
P. Sachidevi 3 Author
G. Seethamma4 Author
Corresponding authorD. VeeraNagendra Kumar Author

Abstract

The myocardium, like other tissues, has enzyme and non-enzyme systems to neutralize free radicals.The present study was investigated the efficacy of Bacopamonnieri in alcohol-induced oxidative stress. In this study we assayedcardiacantioxidantenzymesand Na+/K+, Ca2+ATPases (membrane bound enzymes). Rats were divided into four equal groups: Normal control (NC), Alcohol treated (Al), Bacopamonnieritreated (Bm) and alcohol plus Bacopamonnieritreated (Al+Bm). Bacopamonnieri was given to the At group for six weeks and cardiacSOD, ascorbic acid, MDA levels and membrane bound enzymes were assayed. Cardiac superoxide dismutase,ascorbic acid, Na+/K+, Mg2+ and Ca2+ATPases activities were significantly (P >001) decreased, whereas malondialdehyde(MDA) levels were elevated in alcohol treatedgroup. However, Bacopamonnieriextract supplementation to the alcohol treated rats reversed these effects and attained the SOD, ascorbic acid, MDA levels and Na+/K+, Ca2+ATPases activitiesto normal levels. This study concludes that alcohol-induced cardiac toxicity was attenuated by Bacopamonnieriextract treatment,thus Bacopamonnieri can used as a regular nutrient to protect the cardiovascular diseases.