The electron deficiency of boron imparts unique coordination capabilities to the element. Boron is versatile in its ability to interact with different classes of proteins due to its reversible covalent mode of interaction with nucleophilic residues. Boron based affinity materials for enriching bioactive molecules is an attractive strategy in targeted drug delivery, electrochemical detection of biologically significant molecules like saccharides, bio separation etc. Boronic acid ligand -functionalised materials such as various types of nano particles, bioactive glasses, polymeric scaffold etc were reported for inhibition against viral entry, biofilm formation, enhancing bone/soft tissue regeneration, construction of pH sensitive drug delivery nano vehicle, detection and separation of biologically significant molecules like saccharides etc.