Diabetes, both type 1 and type 2, is a significant risk factor for the development and progression of chronic kidney disease (CKD). The relationship between diabetes and CKD is multifaceted and involves various pathophysiological mechanisms. Chronic kidney disease (CKD) is an important public health concern in developed countries because of both the number of people affected and the high cost of care when prevention strategies are not effectively implemented. Prevention should start at the governance level with the institution of multisectoral polices supporting sustainable development goals and ensuring safe and healthy environments. The TGF-beta family of cytokines are ubiquitous, multifunctional, and essential to survival. They play important roles in growth and development, inflammation and repair and host immunity. The mammalian TGF-beta isoforms (TGF-beta 1, beta 2 and beta 3) are secreted as latent precursors and have multiple cell surface receptors of which at least two mediate signal transductions. The role off tgfbr1, tgfbr2 in chronic kidney disease, in ambiguous in association with the smad4, smad6, epo production. Diabetes plays a crucial role in the kidney failure in this study we examine the involvement of the TGF Beta and SMAD gene protein. Targeting of other type of the SMAD protein in the various disease provide the salient finding and their role illustrated till date.