Various imaging modalities can show the normal breast architecture. An interventionist should be familiar with normal breast anatomy when performing imaging examinations in order to avoid mistaking normal anatomy for a pathologic disease and causing injury to a patient by performing an unneeded procedure. Planning safe breast interventions and avoiding unintended procedural problems requires a thorough understanding of breast anatomy. The major anatomical components of the breast are located above the chest wall and comprise skin, fat, fascial layers, Cooper ligaments, fibroglandular tissue, lymphatics, and neurovascular structures. The breast parenchyma in men often consists only of fat and lacks fibroglandular tissue. Age-related changes in fibroglandular tissue volumes in women result in a predominance of fat in the breasts for many women. During the fourth through twelfth weeks of gestation, skin precursor cells genetically and hormonally influence the development of the breast. The resulting breast bud then continues to lengthen and branch throughout the remaining weeks of gestation, forming a complex network of radially arranged breast ducts that connect the nipple with the mammary lobules. The internal thoracic artery is the major arterial blood vessel that supplies blood to the breast, however the intercostal and lateral thoracic arteries also provide blood to the breast. With some variance in communication channels between deep and superficial venous and lymphatic channels, the venous anatomy and lymphatic drainage of the breast largely parallel the artery anatomy. It is common practice to evaluate the degree of breast disease and inform breast therapies using tools that evaluate breast vascular structures (such as contrast-enhanced breast magnetic resonance imaging) and lymphatic structures (such as nuclear medicine lymphoscintigraphy).